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|Pronunciation||/ ɜːr b ə ˈ s ɑːr t ən /|
|Trade names||Avapro, others|
|License data||EU EMA: by INN, US FDA: Irbesartan|
|Pregnancy category||AU: D|
|Routes of administration||By mouth|
|ATC code||C09CA04 ( WHO )|
|Legal status||AU: S4 (Prescription only) UK: POM (Prescription only) US: ℞-only|
|Bioavailability||60% to 80%|
|Elimination half-life||11 h to 15 h|
|Excretion||Kidney 20%, faecal 65%|
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Mg hydrochlorothiazide to 300 mg irbesartan once daily in patients not adequately controlled on 300 mg irbesartan alone resulted in further placebo-corrected diastolic blood pressure reductions at trough 24 hours post-dosing of 6.
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Hen the individual components of the primary endpoint were analysed, no effect in all cause mortality was observed, while a positive trend in the reduction in ESRD and a significant reduction in doubling of serum creatinine were observed. Subgroups consisting of gender, race, age, duration of diabetes, baseline blood pressure, serum creatinine, and albumin excretion rate were assessed for treatment effect.
Irbesartan significantly reduced the relative risk in the primary combined endpoint of doubling serum creatinine, end-stage renal disease ESRD or all cause mortality. Approximately 33% of patients in the irbesartan group reached the primary renal composite endpoint compared to 39% and 41% in the placebo and amlodipine groups20% is avalide back on the market risk reduction versus placebo p.
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Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect: Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or irbesartan shortage unusual hoarseness; or swelling of the mouth, face, lips, tongue, Signs of high blood sugar like confusion, feeling sleepy, more thirst, more hungry, passing urine more often, flushing, fast breathing, or Signs of kidney problems like unable to pass urine, change in how much urine is passed, blood in the urine, or a big weight gain.
Irbesartan shortage of fluid and irbesartan shortage problems like mood changes, confusion, muscle pain or weakness, a heartbeat that does not feel normal, very bad dizziness or passing out, fast heartbeat, more thirst, seizures, feeling very tired or weak, not hungry, unable to pass urine or change in the amount of urine produced, dry mouth, dry eyes, or very bad upset stomach or throwing up.
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Taux de potassium: avalide generic de ce m dicament peut modifier les taux de potassiumsanguins, en particulier lorsqu'on l'utilise pour le traitement de l'insuffisancecardiaque ou lorsqu'on le prend avec certains autres m dicaments appel sinhibiteurs de l'ECA ou avec certains diur tiques comme la spironolactone. Si votre pression art rielle est basseou si vous commencez seulement prendre ce m dicament, allez-y lentement quandvous passez de la position allong e la position debout afin de r duire lerisque d' tourdissements.
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Patients were followed for a mean duration of 2. of patients received the target dose of irbesartan more than 50% of the time.
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Irbesartan belongs to a class of drugs called angiotensin receptor blockers ARBs It works by relaxing blood vessels so that blood can flow more easily. Lowering high blood pressure helps avalide generic strokes, heart attacks, and kidney problems.
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