If you notice other effects not listed above, contact your doctor or pharmacist. Detrol la (tolterodine) pkg. 4 mg 10 package quantity.
-fold increase in peak plasma concentrations or AUC, respectively, of tolterodine. Therefore, the manufacturer states that concomitant use of tolterodine with other potent CYP3A4 inhibitors, such as azole antifungals e.
Concomitant use of ketoconazole 200 mg daily with tolterodine as conventional tablets in healthy individuals with poor-oxidizer phenotypes see Pharmacokinetics: Elimination detrol la samples resulted in a 2- or 2. However, since the sum of the serum concentrations of unbound tolterodine and the 5-hydroxymethyl metabolite was only 25% higher than that in patients receiving tolterodine without fluoxetine, the manufacturer states that adjustment of tolterodine tartrate dosage is not necessary in patients detrol la samples concomitant fluoxetine therapy.
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Generic detrol la Generic detrol la, MD: Agency for Healthcare Policy and Research; 1996. Urinary incontinence in adults: acute and chronic management. A review of the evidence regarding the long-term outcome of the overactive bladder. Clinical Practice Guideline #2 AHCPR Publication No. 96-0682. Garnett S, Abrams P. The natural history of the overactive bladder and detrusor overactivity.
Detrol la samples A decision should be made whether to discontinue nursing or to discontinue DETROL double-blind, 12-week studies were conducted using tolterodine extended release DETROL LA detrol la samples. It is not known whether tolterodine is excreted in human milk; therefore, DETROL should not be administered during nursing.
Therefore, DETROL should be used during pregnancy only if the potential benefit for the mother justifies the potential risk to the fetus. The offspring regained the weight during the maturation phase. of female mice treated with tolterodine 20 mg/kg/day during the lactation period had slightly reduced body weight gain.
It is not known whether tolterodine is distributed into human milk. mg/kg daily subcutaneously approximately 3 times the human systemic exposure at the recommended human dosage based on AUC comparisons There are no adequate and controlled studies to date using tolterodine tartrate in pregnant women, and the drug should be used during pregnancy only when the potential benefits justify the possible risk to the generic detrol la ― detrol la generic launch.
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When administered for 2 weeks prior to mating and during gestation in female mice, tolterodine tartrate dosages of 20 generic detrol la daily about 15 times the human generic detrol la exposure based on AUC comparisons were not associated with impairment of fertility or reproductive performance.
In addition, in male mice receiving tolterodine tartrate dosages of 30 mg/kg generic detrol la, no adverse effects on fertility were observed.
Generic detrol la generic detrol la See Cautions: Precautions and Contraindications. Other adverse effects that have been reported generic detrol la at least 1% of patients receiving tolterodine tartrate include arthralgia, chest pain, dysuria, infection, flu-like symptoms, and sinusitis.
Associated torsades de pointes has not been reported during postmarketing experience with tolterodine conventional tablets or extended-release capsules. However, a causal relationship of the drug to some of these adverse effects has not been established.
Tachycardia, palpitations, and peripheral edema have been reported in patients receiving tolterodine during postmarketing surveillance; however, a causal relationship to the drug has not been established.
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6 or 5. 3 or 11. eart rate increased by a mean of 2 or 6. 4 msec increase from baseline as measured by machine or manually, respectively than a generic detrol la of 2 mg twice daily 1.
beats/minute following administration of tolterodine 2 mg twice daily or 4 mg twice daily, respectively. 1 msec increase from baseline as measured by machine or manually, respectively Prolongation of the QTc interval was found to correlate with plasma tolterodine concentration and generic detrol la more pronounced in individuals with the poor-oxidizer phenotype than in those with the extensive-oxidizer phenotype.
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- Generic detrol la http://humanos.cfm.org.br/detrol-la-samples-5207311/generic-detrol-la Inform patients that antimuscarinic agents such as DETROL LA may have side effects including blurred vision, dizziness, or drowsiness. Mean generic detrol la from baseline in weekly incontinence episodes, urinary frequency, and volume voided between placebo and DETROL LA are summarized in Table 4.
- Generic detrol la 2004 Jun. 8-53. ubMed: generic detrol la T, Fetscher C, Krege S, Michel MC: Signal transduction underlying carbachol-induced contraction of human urinary bladder. J Pharmacol Exp Ther.
- The majority of patients were Caucasian (95% and female (81% with a mean age of 61 years (range, 20 to 93 years) In the study, 642 patients (42% were 65 to 93 years of age. A total of 507 patients received DETROL LA 4 mg once daily in the morning and generic detrol la received placebo. generic detrol la
- You may report side effects to FDA at 1-800-FDA-1088. Before taking Detrol, tell your doctor generic detrol la all other medicines you use, especially: narcotic medication such as levomethadyl (Orlaam) or methadone (Dolophine, Methadose) antibiotics such as azithromycin (Zithromax) clarithromycin (Biaxin) erythromycin (E. Call your generic detrol la for medical advice about side effects.
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The effect on the QT interval appeared greater for 8 mg/day two times the therapeutic dose compared to 4 mg/day and was more pronounced in CYP2D6 poor metabolizers PM than extensive metabolizers EMs The effect of tolterodine 8 mg/day was not as large as that observed after four days of therapeutic dosing with the active control moxifloxacin. In a study of the effect of tolterodine immediate release tablets generic detrol la the QT intervalsee CLINICAL PHARMACOLOGY 12.
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Tolterodine may generic detrol la your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Breaking or opening the pill may cause too much of the drug to be released at one time. Swallow it whole.
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In healthy men with the extensive-oxidizer phenotype, apparent oral clearance of tolterodine is about 8900 or 6917 mL/minute following single 4 mg or multiple 4 mg twice daily oral doses of the drug administered as conventional tablets respectively, generic detrol la in healthy men with the poor-oxidizer phenotype, apparent oral clearance of tolterodine under the same conditions reportedly is about 283 or 183 mL/minute, respectively.
The 5-carboxylic acid and N-dealkylated 5-carboxylic acid metabolites account for about 51 and 29% respectively, of the metabolites recovered in urine. In those with poor-oxidizer phenotype, less than 2. of the dose was excreted as unchanged tolterodine and less than 1% generic detrol la the 5-hydroxymethyl metabolite.
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Dyspepsia, diarrhea, and weight gain also have been reported in patients receiving tolterodine. Constipation was reported in about. r 4-5% of patients receiving tolterodine tartrate 1 mg twice daily as conventional tablets, tolterodine tartrate 2 mg twice daily generic detrol la conventional tablets, tolterodine tartrate 4 mg once daily as extended-release capsules, or placebo, respectively.
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Respectively, median increases in the volume of urine voided per micturition of 34 or 14 mL, respectively, and median decreases in the number of incontinence episodes per week of 11. with conventional tolterodine tartrate tablets or other anticholinergic agents and untreated patients, generic detrol la with tolterodine tartrate 4 mg once daily in the morning as extended-release capsules or placebo resulted in median decreases in the number of micturitions per 24 hours of 1.
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For this generic detrol la, the following should be considered: Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Generic detrol la tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. This is a decision you and your doctor will make.
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Darouiche RO, Green BG, Donovan WH, Chen D, Schwartz M, Merritt J, et al. Medline.
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Swallow the extended-release capsule whole with water. It is very important that you read and understand this information. Be sure to ask your doctor about anything you do not understand.
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Can this be due to the Detrol. That is when he started me on Detrol La. ince then I get off and on bad pain over the right kidney area. .