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Single oral doses up to 16 mg have been studied in human volunteers with no acute toxic effects reported. Dryness and irritation, conjunctivitis, blurred vision, glaucoma, increased intraocular pressure, and cataracts. Cases of growth suppression have been reported for intranasal corticosteroids, including Fluticasone Propionate Nasal Spray, Halobetasol propionate cream over the counter see PRECAUTIONS: Pediatric Use Chronic overdosage may result in signs/symptoms of hypercorticism see PRECAUTIONS Intranasal administration of 2 mg 10 times the recommended dose of fluticasone propionate twice daily for 7 days to healthy human volunteers was well tolerated.

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