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The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. Atorvastatin (atorlip-10) packaging 10 mg 30 amount of packaging.

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Atorvastatin 40mg Film coated Tablets should be used with caution fda atorvastatin patients with hepatic impairment see sections 4. and 5. and 4. fda atorvastatin

Atorvastatin
Clinical data
Pronunciation/ ə ˌ t ɔːr v ə ˈ s t æ t ən /
Trade namesLipitor, Atorva, others
AHFS/Drugs.comMonograph
MedlinePlusa600045
License dataUS  DailyMed:  42465, US   FDA: Atorvastatin
Pregnancy categoryAU: D US: X (Contraindicated)
Routes of administrationBy mouth
ATC codeC10AA05 ( WHO )
Legal status
Legal statusAU: S4 (Prescription only) UK: POM (Prescription only) US: ℞-only
Pharmacokinetic data
Bioavailability12%
MetabolismLiver (CYP3A4)
Elimination half-life14 hours
ExcretionBile

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Atorvastatin 10 mg/day had the lowest acquisition cost per percent fda atorvastatin in LDL-cholesterol levels among fda atorvastatin dosages of the HMG-CoA reductase inhibitors investigated. Pharmacoeconomic studies have shown lipid-lowering with atorvastatin to be cost effective in patients with CHD, men with at least one risk factor for CHD and women with multiple risk factors for CHD.

Atorvastatin has been fda atorvastatin to be more cost effective than most other HMG-CoA reductase inhibitors, in terms of cost per year of life saved and cost of achieving target LDL-cholesterol levels.

Because of the potential for serious adverse reactions, women taking Lipitor should not breast-feed their infants see section 4. Atorvastatin is contraindicated during fda atorvastatin see section 4. Treatment With Ezetimibe Plus Low-Dose Atorvastatin Compared With Higher- Dose Atorvastatin Alone. Michael Piorkowski, Journal of the ... Following concomitant use of fda atorvastatin 40 mg as a single dose and itraconazole 200 mg once daily for 4 days atorvastatin peak plasma concentration and area under the plasma concentration-time curve AUC were increased by 20% and 3.

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  • Fda atorvastatin There have been reports of rhabdomyolysis fda atorvastatin some fatalities) in patients receiving fusidic acid and statins in combination (see section 4. Atorvastatin must not fda atorvastatin co-administered with systemic formulations of fusidic acid or within 7 days of stopping fusidic acid treatment. In patients where the use of systemic fusidic acid is considered essential, statin treatment should be discontinued throughout the duration of fusidic acid treatment.
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  • Fda atorvastatin It can raise your HDL-C ("good" cholesterol) as well. LIPITOR is a prescription medicine that lowers cholesterol in the blood. It lowers the LDL-C ("bad" cholesterol) fda atorvastatin triglycerides in your blood.
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  • Fda atorvastatin As eluded to in a previous post, there are differences in half lives, routes of fda atorvastatin, Side effects, drug interactions, potency etc it takes about 4-5 half lives to achieve steady state and that is also best acheived if meds are taken at the same time each day (avoids extended troughs which may become subtherapeutic) he safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U. Federal Government. there is limited fda atorvastatin for any difference in end outcome of mortality between the different statins. fda atorvastatin

The recommended initial oral dosage of atorvastatin in adults for the management of primary hypercholesterolemia heterozygous familial or nonfamilial or fda atorvastatin dyslipidemia is 10 or 20 mg once daily. The manufacturer states that patients requiring reductions in LDL-cholesterol fda atorvastatin more than 45% may be started on an atorvastatin dosage of 40 mg daily.

In patients older than 75 years of age with clinical Fda atorvastatin, use of statin therapy should be individualized based on the potential benefits, adverse effects, drug interactions, and patient preferences; it is reasonable to fda atorvastatin initiating or continuing moderate-intensity statin therapy in such patients if tolerated.

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Fda atorvastatin The fixed-combination preparation containing atorvastatin and amlodipine Caduet may be used as a substitute for individually titrated drugs. In patients currently receiving atorvastatin and amlodipine, the initial dosage of the fixed-combination preparation should be the equivalent of titrated dosages of atorvastatin and amlodipine. Increased amounts of atorvastatin, amlodipine, fda atorvastatin both components may be added for additional antilipemic, antianginal, or antihypertensive effects.

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Tablet name Atorvastatin
Atorvastatin all product names
Active substanceatorlip-10
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Indicated by decreased serum triglycerides, decreased LDL, cholesterol, and modest increases in HDL cholesterol. Reduces risk of Hypersensitivity to simvastatin; fda atorvastatin liver disease; pregnancy category X lactation.

HMG-CoA reductase inhibitors increase HDL cholesterol, fda atorvastatin decrease LDL cholesterol, and total cholesterol synthesis. Hypercholesterolemia alone or in combination with bile acid sequestrants familial hypercholesterolemia.

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    When atorvastatin is used in fixed combination with amlodipine, interactions associated with amlodipine should be considered. No formal drug interaction studies have been performed to date with the fixed-combination preparation containing atorvastatin and amlodipine.

    Adverse effects reported in 2% or more of patients receiving atorvastatin fda atorvastatin clinical trials that occurred more frequently than with placebo include nasopharyngitis, arthralgia, diarrhea, pain in extremity, urinary tract infection, dyspepsia, nausea, musculoskeletal fda atorvastatin, muscle spasms, myalgia, insomnia, and pharyngolaryngeal pain.

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    Atorvastatin was not found to be carcinogenic in rats, but high doses in mice resulting in 6-11 fold the AUC0-24h reached in humans at the highest recommended dose fda atorvastatin hepatocellular adenomas in males fda atorvastatin hepatocellular carcinomas in females. Atorvastatin was negative for mutagenic and clastogenic potential in a battery source 4 in vitro tests and 1 in vivo assay.

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    Low-density lipoprotein LDL is formed from VLDL and is catabolised primarily through the high affinity to LDL LDL receptor Atorvastatin fda atorvastatin plasma cholesterol and lipoprotein serum concentrations by inhibiting HMG-CoA reductase and subsequently cholesterol biosynthesis in the liver and increases the number of hepatic LDL receptors on the cell surface for enhanced uptake and catabolism of LDL. Atorvastatin reduces LDL production and the number fda atorvastatin LDL particles.

    Pharmacotherapeutic group: Lipid modifying agents, HMG-CoA-reductase inhibitors, ATC code: C10AA05 Atorvastatin is a selective, competitive inhibitor of HMG-CoA reductase, the rate-limiting enzyme responsible for the conversion of 3-hydroxy-3-methyl-glutaryl-coenzyme A to mevalonate, fda atorvastatin precursor of sterols, including cholesterol.

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    0 mg lactose monohydrate. Atorvastatin is indicated as an fda atorvastatin to diet for reduction of elevated total cholesterol total-C LDL-cholesterol LDL-C apolipoprotein B, and triglycerides in adults, adolescents fda atorvastatin children aged 10 years or older with primary fda atorvastatin including familial hypercholesterolaemia heterozygous variant or combined mixed hyperlipidaemia Corresponding to Types IIa and IIb of the Fredrickson classification when response to diet and other nonpharmacological measures is inadequate.

    Atorvastatin is also indicated to reduce total-C and LDL-C in adults with homozygous familial hypercholesterolaemia as an adjunct to other lipid-lowering treatments e. ach film-coated tablet contains 80 mg atorvastatin as atorvastatin calcium trihydrate Each Atorvastatin 80 fda atorvastatin film-coated tablet contains 218.

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    During the 26-week double-blind phase, treatment with atorvastatin 10-20 mg daily resulted in mean fda atorvastatin of 31% in total cholesterol, 40% in LDL-cholesterol, 34% in apo B, fda atorvastatin 12% in triglyceride concentrations, while concentrations of these lipoprotein fractions in placebo recipients changed minimally. ov In a double-blind, placebo-controlled study followed by an open-label phase 187 boys and postmenarchal girls 10-17 years of age with heterozygous familial hypercholesterolemia fda atorvastatin severe hypercholesterolemia mean baseline LDL-cholesterol concentration of 219-230 mg/dL were randomized to receive either atorvastatin 10 mg daily fda atorvastatin the first 4 weeks, increased to 20 mg daily if LDL-cholesterol concentration exceeded 130 mg/dL or placebo for 26 weeks; after 26 weeks of the double-blind phase, all patients entered an open-label phase and received atorvastatin for an additional 26 weeks.

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    The European Medicines Agency has waived the obligation to fda atorvastatin the results of studies with atorvastatin in children aged 0 to less than 6 years in the treatment of heterozygous hypercholesterolaemia and in children aged 0 to less than 18 years in the treatment of homozygous familial hypercholesterolaemia, combined mixed hypercholesterolaemia, primary hypercholesterolaemia and in the prevention of cardiovascular events see section 4.

    There was no Investigator-assessed fda atorvastatin effect noted in height, weight, BMI by age or by gender by visit. TABLE 3 Lipid-lowering Effects of Atorvastatin in Adolescent Boys and Girls with Heterozygous Familial Hypercholesterolemia mmol/L Heterozygous Familial Hypercholesterolaemia in Paediatric Patients aged 10 17 years old A compassionate use study in patients with severe hypercholesterolaemia including homozygous hypercholesterolaemia included 46 paediatric patients treated with atorvastatin titrated according to response some subjects received 80 mg atorvastatin per day Fda atorvastatin study lasted 3 years: LDL-cholesterol was lowered by 36 The long-term efficacy of atorvastatin therapy in childhood to reduce morbidity and mortality fda atorvastatin adulthood has not been established.

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    There have been rare postmarketing reports of fatal and non-fatal hepatic failure in patients taking statins, including atorvastatin. These elevations in transaminases were generally asymptomatic, not associated with cholestasis, and returned to baseline after discontinuation of therapy or with continued treatment.

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